The Church of Sant'Egidio, located in the Piazza di Sant'Egidio, is named after Giles the Hermit, a popular figure in the Middle Ages and the patron saint of people who have disabilities. It stands near the former location of San Lorenzo in Janiculo, which, being in a state of disrepair, was granted to a devout butcher, Agostino Lancelloti, in 1610. Lancelloti restored the church, changed its name to Sant'Egidio, and gave it over to the Carmelite nuns to become part of their convent abutting the piazza. The nuns went on to demolish the former Sant'Egidio and rebuild the church nearby in 1630 in its present form, also dedicating it to the Madonna del Carmelo. The church contains a single nave, as well as a painting depicting Saint Giles by Pomarancio. Today, the church is home to the headquarters of the Community of Sant'Egidio, a Catholic association now present in over 70 countries and dedicated to prayer, peace, and helping the poor.

This piazza is also home to the Museo di Roma Trastevere and many popular eating spots.

There are no listed visiting hours for this location.